![Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma - Shida Xiong, Wei Huang, Xiaoqiang Liu, Qian Chen, Yi Ding, Haoxuan Huang, Ru Zhang, Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma - Shida Xiong, Wei Huang, Xiaoqiang Liu, Qian Chen, Yi Ding, Haoxuan Huang, Ru Zhang,](https://journals.sagepub.com/cms/10.1177/09636897221077921/asset/images/large/10.1177_09636897221077921-fig6.jpeg)
Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma - Shida Xiong, Wei Huang, Xiaoqiang Liu, Qian Chen, Yi Ding, Haoxuan Huang, Ru Zhang,
![Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fsrep24218/MediaObjects/41598_2016_Article_BFsrep24218_Fig4_HTML.jpg)
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports
![Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo | PNAS Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo | PNAS](https://www.pnas.org/cms/10.1073/pnas.1522367113/asset/94056304-f1b1-4c19-a670-0b6a533cd7eb/assets/graphic/pnas.1522367113fig8.jpeg)
Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo | PNAS
![SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma | Journal of Experimental & Clinical Cancer Research | Full Text SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-022-02284-7/MediaObjects/13046_2022_2284_Fig7_HTML.png)
SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma | Journal of Experimental & Clinical Cancer Research | Full Text
Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib
![Frontiers | Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs Frontiers | Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs](https://www.frontiersin.org/files/Articles/573743/fonc-10-01517-HTML/image_m/fonc-10-01517-g001.jpg)
Frontiers | Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs
![Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy | Antioxidants & Redox Signaling Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy | Antioxidants & Redox Signaling](https://www.liebertpub.com/cms/10.1089/ars.2013.5795/asset/images/medium/figure6.gif)
Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy | Antioxidants & Redox Signaling
![Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis | Cell Death & Disease Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fcddis.2012.125/MediaObjects/41419_2012_Article_BFcddis2012125_Fig1_HTML.jpg)
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis | Cell Death & Disease
![Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1 - ScienceDirect Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1 - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2213231721002731-ga1.jpg)
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1 - ScienceDirect
![Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication | Bentham Science Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication | Bentham Science](https://www.eurekaselect.com/images/graphical-abstract/acamc/15/9/004.jpg)
Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication | Bentham Science
![The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation - ScienceDirect The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2213231716300192-fx1.jpg)
The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation - ScienceDirect
![Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer | Cell Death Discovery Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer | Cell Death Discovery](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41420-020-00296-w/MediaObjects/41420_2020_296_Fig1_HTML.png)
Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer | Cell Death Discovery
![PDF] The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. | Semantic Scholar PDF] The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/80cbd857543023682a105253c4bdb96a358339a4/4-Figure1-1.png)
PDF] The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. | Semantic Scholar
![Cancers | Free Full-Text | Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer Cancers | Free Full-Text | Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer](https://www.mdpi.com/cancers/cancers-13-03250/article_deploy/html/images/cancers-13-03250-g001.png)
Cancers | Free Full-Text | Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer
![IJMS | Free Full-Text | MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis IJMS | Free Full-Text | MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis](https://pub.mdpi-res.com/ijms/ijms-20-00072/article_deploy/html/images/ijms-20-00072-ag.png?1570871389)
IJMS | Free Full-Text | MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis
![Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells | Scientific Reports](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fsrep24218/MediaObjects/41598_2016_Article_BFsrep24218_Fig6_HTML.jpg)